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Aside from the "skip level" or "out-of-map" bug (doesn't work anymore), it's no longer possible to access Slough Creek early. The trick formerly involved starting a multiplayer game in Slough Creek. While the level was loaded in memory, you'd then hit "New game" on single player and start a new game in Slough Creek rather than being in Amethyst Mountain, with no mate. You'd still be able to have pups, but throughout the level, no mate would be present. Needless to say difficulty increased significantly due to there being no guardian in your absence. 

For the most part, this video shows how to bypass Amethyst Mountain early and load Slough Creek into memory, but it was done with version 2.0.3. Even with 2.0.3 installed, you still won't be able to replicate the glitch due to multiplayer being inaccessible to older versions and, as of 2.5+, this glitch has been patched.

Hope that helps. ~Neam